Down-regulation of fragile histidine triad expression in prostate carcinoma
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چکیده
منابع مشابه
Expression of the Fragile Histidine Triad Gene in Laryngeal Carcinoma
The aim of this study was to investigate Fragile Histidine Triad Gene (FHIT) expression in laryngeal squamous cell carcinoma. The paraffin embedded tissue blocks of 64 laryngeal squamous cell carcinoma specimens were enrolled in the study. FHIT expression was detected by an immunohistochemical method. Rabbit polyclonal antibody was used for immunohistochemical study. FHIT expression was low in ...
متن کاملFHIT (fragile histidine triad)
Fhit protein is a tumor suppressor with reduced or no expression in many types of cancer. Fhit expression is more frequently lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1 and BRCA2 and MSH2. In vitro Fhit acts as a hydrolase that cleaves diadenosine triphosphate (Ap3A) to ADP and AMP. The Fhit-Ap3A enzyme-substrate complex appears to...
متن کاملAdvances in Brief Clinicopathological Significance of Fragile Histidine Triad Transcription Protein Expression in Breast Carcinoma
The fragile histidine triad (Fhit) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Loss of Fhit expression is an important step in tumor progression from premalignancy, to in situ, to invasive breast carcinoma. To determine whether the absence of Fhit protein correlates with other established pathological-clinical ...
متن کاملN-Terminal Domain of Fragile Histidine Triad Exerts Potent Cytotoxic Effect in HT1080 Cells
Fragile histidine triad (FHIT) serves a critical function as a tumor suppressor that inhibits p53 degradation by mouse double minute 2 (MDM2). The functional domains of FHIT involved in tumor inhibition was interpreted. In-silico screening data were employed to construct truncated forms of FHIT to assess their cytotoxic effects on the HT1080 cell line. Full FHIT expression was confirmed by west...
متن کاملClinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.
The fragile histidine triad (Fhit) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Loss of Fhit expression is an important step in tumor progression from premalignancy, to in situ, to invasive breast carcinoma. To determine whether the absence of Fhit protein correlates with other established pathological-clinical ...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11201